This study aims to explore how epigenetic factors affect learning and memory in academic performanc. Previous studies have shown that genetic factors affect about 60% of the variation in scientific learning (Polmin & Haworth, 2008). However, recent studies have indicated that the interaction of genes with the environment (epigenetics) may be the most important factor affecting brain development, brain plasticity, and learning behavior. Environmental factors activate intracellular signaling pathways and alter the state of epigenetic genes. Epigenetic factors affect neuroplasticity through neurophysiology, which in turn regulates learning and memory. One of the epigenetic factors, non-coding small molecule RNA (MicroRNA) is currently considered to be the primary factor regulating brain development and cognitive learning memory. The objective of this study was to explore the relationship between non-coding small molecule RNA in neural pathways related to brain plasticity, cognitive ability, and scientific learning effectiveness. In addition, this study also examined how genetic factors, including genetics and epigenetics, affect adolescent cognitive function and scientific learning memory. Discovering how learning environments interact with genetics will provide important insights into the academic and practical aspects of adaptive learning.